Publication: Phylogenetic Analysis of the 2020 West Nile Virus (WNV) Outbreak in Andalusia (Spain)
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Identifiers
Date
2021-05-05
Authors
Casimiro-Soriguer, Carlos S.
Perez-Florido, Javier
Fernandez-Rueda, Jose L.
Pedrosa-Corral, Irene
Guillot-Sulay, Vicente
Lorusso, Nicola
Martinez-Gonzalez, Luis Javier
Navarro-Marí, Jose M.
Dopazo, Joaquin
Sanbonmatsu-Gámez, Sara
Advisors
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Publisher
MDPI AG
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Abstract
During recent decades West Nile Virus (WNV) outbreaks have continuously occurred in the Mediterranean area. In August 2020 a new WNV outbreak affected 71 people with meningoencephalitis in Andalusia and six more cases were detected in Extremadura (south-west of Spain), causing a total of eight deaths. The whole genomes of four viruses were obtained and phylogenetically analyzed in the context of recent outbreaks. The Andalusian viral samples belonged to lineage 1 and were relatively similar to those of previous outbreaks which occurred in the Mediterranean region. Here we present a detailed analysis of the outbreak, including an extensive phylogenetic study. As part on this effort, we implemented a local Nextstrain server, which has become a constituent piece of regional epidemiological surveillance, wherein forthcoming genomes of environmental samples or, eventually, future outbreaks, will be included.
Description
MeSH Terms
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Central Nervous System Infections::Central Nervous System Viral Diseases::Encephalitis::Encephalitis, Viral::Encephalitis, Arbovirus::West Nile Fever
Medical Subject Headings::Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Encephalitis Viruses::Encephalitis Viruses, Japanese::West Nile virus
Medical Subject Headings::Information Science::Information Science::Classification::Phylogeny
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Central Nervous System Infections::Central Nervous System Viral Diseases::Encephalitis::Encephalitis, Viral::Encephalitis, Arbovirus::West Nile Fever
Medical Subject Headings::Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Encephalitis Viruses::Encephalitis Viruses, Japanese::West Nile virus
Medical Subject Headings::Information Science::Information Science::Classification::Phylogeny
DeCS Terms
CIE Terms
Keywords
West Nile virus, Outbreak, Meningoencephalitis, Epidemiology, Phylogeny, Whole genome sequencing, Fiebre del Nilo occidental, Brotes de enfermedades, Meningoencefalitis, Epidemiología, Filogenia, Secuenciación completa del genoma
Citation
Casimiro-Soriguer CS, Perez-Florido J, Fernandez-Rueda JL, Pedrosa-Corral I, Guillot-Sulay V, Lorusso N, et al. Phylogenetic Analysis of the 2020 West Nile Virus (WNV) Outbreak in Andalusia (Spain). Viruses. 2021; 13(5):836.
Collections
Instituto de Investigación Biomédica de Sevilla (IBIS)
Centro Pfizer-Andalucía de Genómica e Investigación Oncológica (GENYO)
CSyC - Servicios Centrales
Instituto de Investigación Biosanitaria de Granada (ibsGRANADA)
SAS - Hospital Universitario Virgen de las Nieves
SAS - Hospital Universitario Virgen del Rocío
Centro Pfizer-Andalucía de Genómica e Investigación Oncológica (GENYO)
CSyC - Servicios Centrales
Instituto de Investigación Biosanitaria de Granada (ibsGRANADA)
SAS - Hospital Universitario Virgen de las Nieves
SAS - Hospital Universitario Virgen del Rocío