Publication: The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
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Date
2021-04-29
Authors
Jimeno, Sonia
Balestra, Fernando R.
Huertas, Pablo
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Frontiers
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Abstract
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.
Description
MeSH Terms
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage::DNA Breaks::DNA Breaks, Double-Stranded
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Single-Stranded
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Homologous Recombination
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Sequence Homology
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nucleoproteins
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Single-Stranded
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Homologous Recombination
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Sequence Homology
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nucleoproteins
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome
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CIE Terms
Keywords
RNA modification, DNA repair, Homologous recombination, DNA resection, R-loop, Procesamiento postranscripcional del ARN, Reparación del ADN, Recombinación homóloga, Estructuras R-loop, ADN
Citation
Jimeno S, Balestra FR, Huertas P. The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair. Front Mol Biosci. 2021 Apr 29;8:664872