Publication: Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.
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2017-10-03
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Fernández-Martínez, Marta
Ruiz Del Castillo, Belén
Lecea-Cuello, Maria Jesús
Rodríguez-Baño, Jesús
Pascual, Álvaro
Martínez-Martínez, Luis
Spanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH)
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Abstract
The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated. The resistance to (one or more) aminoglycosides was significantly higher in Kp-ESBL (104/139, 74.8%) than in Ec-ESBL (171/420, 40.7%; p
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MeSH Terms
Aminoglycosides
Anti-Bacterial Agents
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Escherichia coli
Humans
Klebsiella pneumoniae
Microbial Sensitivity Tests
Prevalence
Spain
beta-Lactamases
Anti-Bacterial Agents
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Escherichia coli
Humans
Klebsiella pneumoniae
Microbial Sensitivity Tests
Prevalence
Spain
beta-Lactamases
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Keywords
Escherichia coli, Klebsiella pneumoniae, Spain, aminoglycoside-modifying enzymes, extended spectrum β-lactamases