%0 Journal Article
%A Fernández-Martínez, Marta
%A Ruiz Del Castillo, Belén
%A Lecea-Cuello, Maria Jesús
%A Rodríguez-Baño, Jesús
%A Pascual, Álvaro
%A Martínez-Martínez, Luis
%A Spanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH)
%T Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.
%D 2017
%U http://hdl.handle.net/10668/12423
%X The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated. The resistance to (one or more) aminoglycosides was significantly higher in Kp-ESBL (104/139, 74.8%) than in Ec-ESBL (171/420, 40.7%; p 
%K Escherichia coli
%K Klebsiella pneumoniae
%K Spain
%K aminoglycoside-modifying enzymes
%K extended spectrum β-lactamases
%~