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Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.

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dc.contributor.authorFernández-Martínez, Marta
dc.contributor.authorRuiz Del Castillo, Belén
dc.contributor.authorLecea-Cuello, Maria Jesús
dc.contributor.authorRodríguez-Baño, Jesús
dc.contributor.authorPascual, Álvaro
dc.contributor.authorMartínez-Martínez, Luis
dc.contributor.authorSpanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH)
dc.date.accessioned2023-01-25T10:07:56Z
dc.date.available2023-01-25T10:07:56Z
dc.date.issued2017-10-03
dc.description.abstractThe in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated. The resistance to (one or more) aminoglycosides was significantly higher in Kp-ESBL (104/139, 74.8%) than in Ec-ESBL (171/420, 40.7%; p 
dc.identifier.doi10.1089/mdr.2017.0102
dc.identifier.essn1931-8448
dc.identifier.pmcPMC5946734
dc.identifier.pmid29727265
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946734/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5946734?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/12423
dc.issue.number4
dc.journal.titleMicrobial drug resistance (Larchmont, N.Y.)
dc.journal.titleabbreviationMicrob Drug Resist
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationHospital Universitario Virgen Macarena
dc.organizationHospital Universitario Virgen Macarena
dc.page.number367-376
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.rights.accessRightsopen access
dc.subjectEscherichia coli
dc.subjectKlebsiella pneumoniae
dc.subjectSpain
dc.subjectaminoglycoside-modifying enzymes
dc.subjectextended spectrum β-lactamases
dc.subject.meshAminoglycosides
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshBacterial Proteins
dc.subject.meshDrug Resistance, Multiple, Bacterial
dc.subject.meshEscherichia coli
dc.subject.meshHumans
dc.subject.meshKlebsiella pneumoniae
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshPrevalence
dc.subject.meshSpain
dc.subject.meshbeta-Lactamases
dc.titlePrevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number24
dspace.entity.typePublication

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Instituto de Investigación Biomédica de Sevilla (IBIS)
SAS - Hospital Universitario Virgen del Rocío
SAS - Hospital Universitario Virgen Macarena

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