Publication: Anaphylaxis to 2 NSAIDs in a Patient Who Tolerated ASA.
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Identifiers
Date
2016
Authors
Bogas, G
Perez-Sanchez, N
Andreu, I
Doña, I
Perkins, J R
Blanca, M
Canto, G
Cornejo-Garcia, J A
Blanca-Lopez, N
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Esmon Publicidad
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Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent cause of drug hypersensitivity [1]. NSAID-induced reactions can be classified into 5 categories: (1) NSAID-exacerbated respiratory disease (NERD); (2) NSAID-exacerbated cutaneous disease (NECD); (3) NSAID-induced urticaria and/or angioedema (NIUA); (4) single NSAID-induced urticaria/angioedema/anaphylaxis (SNIUAA); and (5) single NSAID-induced delayed hypersensitivity reactions (SNIDR) [2]. Patients in the first 3 categories react to NSAIDs from various chemical groups in a nonallergic type of drug hypersensitivity known as cross-intolerance. The mechanism involved in these reactions is thought to be related to an imbalance in the arachidonic acid metabolic pathway leading to increased release of cysteinyl leukotrienes.
Description
MeSH Terms
Anaphylaxis
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Humans
Male
Middle Aged
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Humans
Male
Middle Aged
DeCS Terms
Antiinflamatorios no esteroideos
Urticaria
Hipersensibilidad a las drogas
Angioedema
Leucotrienos
Ácido araquidónico
Urticaria
Hipersensibilidad a las drogas
Angioedema
Leucotrienos
Ácido araquidónico
CIE Terms
Keywords
ASA tolerance, Anaphylaxis, Cross-intolerance, NSAID hypersensitivity, Selective reactions, Hipersensibilidad a AINE, Intolerancia cruzada, Reacciones selectivas, Anafilaxia, Tolerancia a AAS
Citation
Bogas G, Pérez-Sánchez N, Andreu I, Doña I, Perkins JR, Blanca M, et al. Anaphylaxis to 2 NSAIDs in a Patient Who Tolerated ASA. J Investig Allergol Clin Immunol. 2016;26(4):266-8