%0 Journal Article
%A Bogas, G
%A Perez-Sanchez, N
%A Andreu, I
%A Doña, I
%A Perkins, J R
%A Blanca, M
%A Canto, G
%A Cornejo-Garcia, J A
%A Blanca-Lopez, N
%T Anaphylaxis to 2 NSAIDs in a Patient Who Tolerated ASA.
%D 2016
%@ 1018-9068
%U http://hdl.handle.net/10668/10312
%X Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent cause of drug hypersensitivity [1]. NSAID-induced reactions can be classified into 5 categories: (1) NSAID-exacerbated respiratory disease (NERD); (2) NSAID-exacerbated cutaneous disease (NECD); (3) NSAID-induced urticaria and/or angioedema (NIUA); (4) single NSAID-induced  urticaria/angioedema/anaphylaxis (SNIUAA); and (5) single NSAID-induced delayed hypersensitivity reactions (SNIDR) [2]. Patients in the first 3 categories react to NSAIDs from various chemical groups in a nonallergic type of drug hypersensitivity known as cross-intolerance. The mechanism involved in these reactions is thought to be related to an imbalance in the arachidonic acid metabolic pathway leading to increased release of cysteinyl leukotrienes.
%K ASA tolerance
%K Anaphylaxis
%K Cross-intolerance
%K NSAID hypersensitivity
%K Selective reactions
%K Hipersensibilidad a AINE
%K Intolerancia cruzada
%K Reacciones selectivas
%K Anafilaxia
%K Tolerancia a AAS
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