Publication:
Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study.

dc.contributor.authorLozano-Lorca, Macarena
dc.contributor.authorBarrios-Rodriguez, Rocio
dc.contributor.authorRedondo-Sanchez, Daniel
dc.contributor.authorCozar, Jose-Manuel
dc.contributor.authorArrabal-Martin, Miguel
dc.contributor.authorGarcia-Caballos, Marta
dc.contributor.authorSalcedo-Bellido, Inmaculada
dc.contributor.authorSanchez-Perez, Maria-Jose
dc.contributor.authorJimenez-Moleon, Jose-Juan
dc.contributor.authorOlmedo-Requena, Rocio
dc.contributor.funderUniversidad de Granada / CBUA
dc.contributor.funderRegional Ministry of Health and Families of Andalusia/Consejería de Salud y Familias de la Junta de Andalucía
dc.date.accessioned2023-05-03T13:44:34Z
dc.date.available2023-05-03T13:44:34Z
dc.date.issued2022-11-21
dc.description.abstractTo analyse the Health-Related Quality of Life (HRQoL) at diagnosis of patients with prostate cancer (PCa) according to tumour extension and urinary symptomatology and to explore factors associated with HRQoL. 408 Controls and 463 PCa cases were included. Eligibility criteria were a new diagnosis of PCa (cases), 40-80 years of age, and residence in the participating hospitals' coverage area for ≥ 6 months before recruitment. HRQoL was evaluated using the 12-Item Short-Form Health Survey, Mental (MCS) and Physical Component Summaries (PCS), and urinary symptoms with the International Prostate Symptom Score. HRQoL scores for all PCa cases, according to tumour extension and urinary symptoms, were compared with controls. In addition, information about lifestyles and comorbidities was collected and its association with low HRQoL (lower scores) were explored using logistic regression models. Overall cases had similar PCS score, but lower MCS score than controls. The lowest standardised scores for both PCS and MCS were reached by cases with severe urinary symptoms and a metastatic tumour [mean (SD); PCS: 41.9 (11.5), MCS: 42.3 (10.3)]. Having "below" PCS and MCS scores was associated with the presence of three or more comorbidities in the cases [aOR = 2.86 (1.19-6.84) for PCS and aOR = 3.58 (1.37-9.31) for MCS] and with severe urinary symptomatology [aOR = 4.71 (1.84-12.08) for PCS and aOR = 7.63 (2.70-21.58) for MCS]. The mental dimension of HRQoL at diagnosis of patients with PCa was lower than in controls, especially for cases with severe urinary symptoms and a metastatic tumour. Comorbidities and urinary symptoms were variables associated with the HRQoL of PCa cases.
dc.description.versionSi
dc.identifier.citationLozano-Lorca M, Barrios-Rodríguez R, Redondo-Sánchez D, Cózar JM, Arrabal-Martín M, García-Caballos M, et al. Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study. Qual Life Res. 2023 Apr;32(4):977-988.
dc.identifier.doi10.1007/s11136-022-03302-z
dc.identifier.essn1573-2649
dc.identifier.pmcPMC10063519
dc.identifier.pmid36409391
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063519/pdf
dc.identifier.unpaywallURLhttps://link.springer.com/content/pdf/10.1007/s11136-022-03302-z.pdf
dc.identifier.urihttp://hdl.handle.net/10668/20708
dc.issue.number4
dc.journal.titleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
dc.journal.titleabbreviationQual Life Res
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationGranada
dc.organizationMetropolitano de Granada
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number977-988
dc.provenanceRealizada la curación de contenido 23/08/2024
dc.publisherSpringer Dordrecht
dc.pubmedtypeJournal Article
dc.relation.projectIDPI-0514-2016
dc.relation.publisherversionhttps://doi.org/10.1007/s11136-022-03302-z
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHealth-related quality of life
dc.subjectProstate cancer
dc.subjectTumour extension
dc.subjectUrinary symptomatology
dc.subject.decsCalidad de vida
dc.subject.decsComorbilidad
dc.subject.decsEncuestas epidemiológicas
dc.subject.decsEstilo de vida
dc.subject.decsHumanos
dc.subject.decsMasculino
dc.subject.decsNeoplasias de la próstata
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshQuality of Life
dc.subject.meshProstatic Neoplasms
dc.subject.meshComorbidity
dc.subject.meshLife Style
dc.subject.meshHealth Surveys
dc.titleHealth-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number32
dspace.entity.typePublication

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