Publication: Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study.
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Identifiers
Date
2022-11-21
Authors
Lozano-Lorca, Macarena
Barrios-Rodriguez, Rocio
Redondo-Sanchez, Daniel
Cozar, Jose-Manuel
Arrabal-Martin, Miguel
Garcia-Caballos, Marta
Salcedo-Bellido, Inmaculada
Sanchez-Perez, Maria-Jose
Jimenez-Moleon, Jose-Juan
Olmedo-Requena, Rocio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Dordrecht
Abstract
To analyse the Health-Related Quality of Life (HRQoL) at diagnosis of patients with prostate cancer (PCa) according to tumour extension and urinary symptomatology and to explore factors associated with HRQoL. 408 Controls and 463 PCa cases were included. Eligibility criteria were a new diagnosis of PCa (cases), 40-80 years of age, and residence in the participating hospitals' coverage area for ≥ 6 months before recruitment. HRQoL was evaluated using the 12-Item Short-Form Health Survey, Mental (MCS) and Physical Component Summaries (PCS), and urinary symptoms with the International Prostate Symptom Score. HRQoL scores for all PCa cases, according to tumour extension and urinary symptoms, were compared with controls. In addition, information about lifestyles and comorbidities was collected and its association with low HRQoL (lower scores) were explored using logistic regression models. Overall cases had similar PCS score, but lower MCS score than controls. The lowest standardised scores for both PCS and MCS were reached by cases with severe urinary symptoms and a metastatic tumour [mean (SD); PCS: 41.9 (11.5), MCS: 42.3 (10.3)]. Having "below" PCS and MCS scores was associated with the presence of three or more comorbidities in the cases [aOR = 2.86 (1.19-6.84) for PCS and aOR = 3.58 (1.37-9.31) for MCS] and with severe urinary symptomatology [aOR = 4.71 (1.84-12.08) for PCS and aOR = 7.63 (2.70-21.58) for MCS]. The mental dimension of HRQoL at diagnosis of patients with PCa was lower than in controls, especially for cases with severe urinary symptoms and a metastatic tumour. Comorbidities and urinary symptoms were variables associated with the HRQoL of PCa cases.
Description
MeSH Terms
Male
Humans
Quality of Life
Prostatic Neoplasms
Comorbidity
Life Style
Health Surveys
Humans
Quality of Life
Prostatic Neoplasms
Comorbidity
Life Style
Health Surveys
DeCS Terms
Calidad de vida
Comorbilidad
Encuestas epidemiológicas
Estilo de vida
Humanos
Masculino
Neoplasias de la próstata
Comorbilidad
Encuestas epidemiológicas
Estilo de vida
Humanos
Masculino
Neoplasias de la próstata
CIE Terms
Keywords
Health-related quality of life, Prostate cancer, Tumour extension, Urinary symptomatology
Citation
Lozano-Lorca M, Barrios-Rodríguez R, Redondo-Sánchez D, Cózar JM, Arrabal-Martín M, García-Caballos M, et al. Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study. Qual Life Res. 2023 Apr;32(4):977-988.