Publication:
Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study.

Loading...
Thumbnail Image

Date

2022-11-21

Authors

Lozano-Lorca, Macarena
Barrios-Rodriguez, Rocio
Redondo-Sanchez, Daniel
Cozar, Jose-Manuel
Arrabal-Martin, Miguel
Garcia-Caballos, Marta
Salcedo-Bellido, Inmaculada
Sanchez-Perez, Maria-Jose
Jimenez-Moleon, Jose-Juan
Olmedo-Requena, Rocio

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Springer Dordrecht
Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

To analyse the Health-Related Quality of Life (HRQoL) at diagnosis of patients with prostate cancer (PCa) according to tumour extension and urinary symptomatology and to explore factors associated with HRQoL. 408 Controls and 463 PCa cases were included. Eligibility criteria were a new diagnosis of PCa (cases), 40-80 years of age, and residence in the participating hospitals' coverage area for ≥ 6 months before recruitment. HRQoL was evaluated using the 12-Item Short-Form Health Survey, Mental (MCS) and Physical Component Summaries (PCS), and urinary symptoms with the International Prostate Symptom Score. HRQoL scores for all PCa cases, according to tumour extension and urinary symptoms, were compared with controls. In addition, information about lifestyles and comorbidities was collected and its association with low HRQoL (lower scores) were explored using logistic regression models. Overall cases had similar PCS score, but lower MCS score than controls. The lowest standardised scores for both PCS and MCS were reached by cases with severe urinary symptoms and a metastatic tumour [mean (SD); PCS: 41.9 (11.5), MCS: 42.3 (10.3)]. Having "below" PCS and MCS scores was associated with the presence of three or more comorbidities in the cases [aOR = 2.86 (1.19-6.84) for PCS and aOR = 3.58 (1.37-9.31) for MCS] and with severe urinary symptomatology [aOR = 4.71 (1.84-12.08) for PCS and aOR = 7.63 (2.70-21.58) for MCS]. The mental dimension of HRQoL at diagnosis of patients with PCa was lower than in controls, especially for cases with severe urinary symptoms and a metastatic tumour. Comorbidities and urinary symptoms were variables associated with the HRQoL of PCa cases.

Description

MeSH Terms

Male
Humans
Quality of Life
Prostatic Neoplasms
Comorbidity
Life Style
Health Surveys

DeCS Terms

Calidad de vida
Comorbilidad
Encuestas epidemiológicas
Estilo de vida
Humanos
Masculino
Neoplasias de la próstata

CIE Terms

Keywords

Health-related quality of life, Prostate cancer, Tumour extension, Urinary symptomatology

Citation

Lozano-Lorca M, Barrios-Rodríguez R, Redondo-Sánchez D, Cózar JM, Arrabal-Martín M, García-Caballos M, et al. Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study. Qual Life Res. 2023 Apr;32(4):977-988.