Publication: Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
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Date
2018-10-16
Authors
Razquin, Cristina
Toledo, Estefanía
Clish, Clary B
Ruiz-Canela, Miguel
Dennis, Courtney
Corella, Dolores
Papandreou, Christopher
Ros, Emilio
Estruch, Ramon
Guasch-Ferré, Marta
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Abstract
Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.
Description
MeSH Terms
Aged
Aged, 80 and over
Cardiovascular Diseases
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2
Female
Humans
Incidence
Lipid Metabolism
Lipids
Male
Metabolomics
Middle Aged
Risk Factors
Aged, 80 and over
Cardiovascular Diseases
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2
Female
Humans
Incidence
Lipid Metabolism
Lipids
Male
Metabolomics
Middle Aged
Risk Factors