Publication:
Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.

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2018-10-16

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Razquin, Cristina
Toledo, Estefanía
Clish, Clary B
Ruiz-Canela, Miguel
Dennis, Courtney
Corella, Dolores
Papandreou, Christopher
Ros, Emilio
Estruch, Ramon
Guasch-Ferré, Marta

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Abstract

Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.

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Aged
Aged, 80 and over
Cardiovascular Diseases
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2
Female
Humans
Incidence
Lipid Metabolism
Lipids
Male
Metabolomics
Middle Aged
Risk Factors

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