RT Journal Article
T1 Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
A1 Razquin, Cristina
A1 Toledo, Estefanía
A1 Clish, Clary B
A1 Ruiz-Canela, Miguel
A1 Dennis, Courtney
A1 Corella, Dolores
A1 Papandreou, Christopher
A1 Ros, Emilio
A1 Estruch, Ramon
A1 Guasch-Ferré, Marta
A1 Gómez-Gracia, Enrique
A1 Fitó, Montserrat
A1 Yu, Edward
A1 Lapetra, José
A1 Wang, Dong
A1 Romaguera, Dora
A1 Liang, Liming
A1 Alonso-Gómez, Angel
A1 Deik, Amy
A1 Bullo, Mónica
A1 Serra-Majem, Lluis
A1 Salas-Salvadó, Jordi
A1 Hu, Frank B
A1 Martínez-González, Miguel A
AB Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend  Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.
YR 2018
FD 2018-10-16
LK http://hdl.handle.net/10668/13096
UL http://hdl.handle.net/10668/13096
LA en
DS RISalud
RD May 10, 2025