%0 Journal Article
%A Razquin, Cristina
%A Toledo, Estefanía
%A Clish, Clary B
%A Ruiz-Canela, Miguel
%A Dennis, Courtney
%A Corella, Dolores
%A Papandreou, Christopher
%A Ros, Emilio
%A Estruch, Ramon
%A Guasch-Ferré, Marta
%A Gómez-Gracia, Enrique
%A Fitó, Montserrat
%A Yu, Edward
%A Lapetra, José
%A Wang, Dong
%A Romaguera, Dora
%A Liang, Liming
%A Alonso-Gómez, Angel
%A Deik, Amy
%A Bullo, Mónica
%A Serra-Majem, Lluis
%A Salas-Salvadó, Jordi
%A Hu, Frank B
%A Martínez-González, Miguel A
%T Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
%D 2018
%U http://hdl.handle.net/10668/13096
%X Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend  Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.
%~