Publication: Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
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2017-02-23
Authors
Pérez-Belmonte, Luis M
Moreno-Santos, Inmaculada
Cabrera-Bueno, Fernando
Sánchez-Espín, Gemma
Castellano, Daniel
Such, Miguel
Crespo-Leiro, María G
Carrasco-Chinchilla, Fernando
Alonso-Pulpón, Luis
López-Garrido, Miguel
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Abstract
Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p
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MeSH Terms
Adipose Tissue
Aged
Coronary Artery Disease
Diabetes Mellitus, Type 2
Female
Humans
Lipid Metabolism
Male
Middle Aged
Pericardium
Risk Factors
Sterol Regulatory Element Binding Protein 1
Sterol Regulatory Element Binding Protein 2
Sterols
Aged
Coronary Artery Disease
Diabetes Mellitus, Type 2
Female
Humans
Lipid Metabolism
Male
Middle Aged
Pericardium
Risk Factors
Sterol Regulatory Element Binding Protein 1
Sterol Regulatory Element Binding Protein 2
Sterols
DeCS Terms
CIE Terms
Keywords
Sterol regulatory element-binding proteins (SREBP), coronary artery disease, epicardial adipose tissue, type-2 diabetes mellitus.