RT Journal Article
T1 Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
A1 Perez-Belmonte, Luis M
A1 Moreno-Santos, Inmaculada
A1 Cabrera-Bueno, Fernando
A1 Sanchez-Espin, Gemma
A1 Castellano, Daniel
A1 Such, Miguel
A1 Crespo-Leiro, Maria G
A1 Carrasco-Chinchilla, Fernando
A1 Alonso-Pulpon, Luis
A1 Lopez-Garrido, Miguel
A1 Ruiz-Salas, Amalio
A1 Becerra-Muñoz, Víctor M
A1 Gomez-Doblas, Juan J
A1 de-Teresa-Galvan, Eduardo
A1 Jimenez-Navarro, Manuel
K1 Sterol regulatory element-binding proteins (SREBP)
K1 coronary artery disease
K1 epicardial adipose tissue
K1 type-2 diabetes mellitus.
AB Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p<0.001) and were identified as independent cardiovascular risk factor for coronary artery disease in patients with type-2 diabetes (SREBP-1: OR 1.7, 95%CI 1.1-2.5, p=0.02; SREBP-2: OR 1.6, 95%CI 1.2-3, p=0.02) and were independently associated with the presence of multivessel CAD, left main and anterior descending artery stenosis, and higher total and LDL cholesterol levels, and lower HDL cholesterol levels, in patients with CAD and diabetes. Conclusions: SREBP genes are expressed in EAT and were higher in CAD patients with diabetes than those patients without CAD or diabetes. SREBP expression was associated as cardiovascular risk factor for the severity of CAD and the poor lipid control. In this preliminary study we suggest the importance of EAT in the lipid metabolism and cardiovascular homeostasis for coronary atherosclerosis of patients with diabetes and highlight a future novel therapeutic target.
PB Ivyspring International Publisher
YR 2017
FD 2017-02-23
LK http://hdl.handle.net/10668/11037
UL http://hdl.handle.net/10668/11037
LA en
NO Pérez-Belmonte LM, Moreno-Santos I, Cabrera-Bueno F, Sánchez-Espín G, Castellano D, Such M, et al. Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study. Int J Med Sci. 2017 Feb 23;14(3):268-274.
NO The authors thank the Cardiovascular Surgery Department of the Virgen de la Victoria Hospital of Malaga for their contribution in collecting samples. We are also grateful to Alicia Guerrero for her technical assistance.This work was supported by grants from the Spanish Ministry of Health (FIS) (PI13/02542, PI11/01661) and Spanish Cardiovascular Research Network (RD12/0042/0030)/CIBERCV Enfermedades Cardiovasculares co-founded by Fondo Europeo de Desarrollo Regional (FEDER). Dr. Luis M. Pérez-Belmonte has the “Contrato Post-MIR Jordi Soler” from Spanish Cardiovascular Research Network (RD12/0042/0030)/CIBERCV Enfermedades Cardiovasculares.
DS RISalud
RD Sep 27, 2025