RT Journal Article
T1 Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
A1 Pérez-Belmonte, Luis M
A1 Moreno-Santos, Inmaculada
A1 Cabrera-Bueno, Fernando
A1 Sánchez-Espín, Gemma
A1 Castellano, Daniel
A1 Such, Miguel
A1 Crespo-Leiro, María G
A1 Carrasco-Chinchilla, Fernando
A1 Alonso-Pulpón, Luis
A1 López-Garrido, Miguel
A1 Ruiz-Salas, Amalio
A1 Becerra-Muñoz, Víctor M
A1 Gómez-Doblas, Juan J
A1 de Teresa-Galván, Eduardo
A1 Jiménez-Navarro, Manuel
K1 Sterol regulatory element-binding proteins (SREBP)
K1 coronary artery disease
K1 epicardial adipose tissue
K1 type-2 diabetes mellitus.
AB Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p
YR 2017
FD 2017-02-23
LK http://hdl.handle.net/10668/11037
UL http://hdl.handle.net/10668/11037
LA en
DS RISalud
RD Apr 15, 2025