Publication:
Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.

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dc.contributor.authorPérez-Belmonte, Luis M
dc.contributor.authorMoreno-Santos, Inmaculada
dc.contributor.authorCabrera-Bueno, Fernando
dc.contributor.authorSánchez-Espín, Gemma
dc.contributor.authorCastellano, Daniel
dc.contributor.authorSuch, Miguel
dc.contributor.authorCrespo-Leiro, María G
dc.contributor.authorCarrasco-Chinchilla, Fernando
dc.contributor.authorAlonso-Pulpón, Luis
dc.contributor.authorLópez-Garrido, Miguel
dc.contributor.authorRuiz-Salas, Amalio
dc.contributor.authorBecerra-Muñoz, Víctor M
dc.contributor.authorGómez-Doblas, Juan J
dc.contributor.authorde Teresa-Galván, Eduardo
dc.contributor.authorJiménez-Navarro, Manuel
dc.date.accessioned2023-01-25T09:44:36Z
dc.date.available2023-01-25T09:44:36Z
dc.date.issued2017-02-23
dc.description.abstractObjectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p
dc.identifier.doi10.7150/ijms.17821
dc.identifier.essn1449-1907
dc.identifier.pmcPMC5370289
dc.identifier.pmid28367087
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370289/pdf
dc.identifier.unpaywallURLhttp://www.medsci.org/v14p0268.pdf
dc.identifier.urihttp://hdl.handle.net/10668/11037
dc.issue.number3
dc.journal.titleInternational journal of medical sciences
dc.journal.titleabbreviationInt J Med Sci
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Universitario Virgen de la Victoria
dc.page.number268-274
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectSterol regulatory element-binding proteins (SREBP)
dc.subjectcoronary artery disease
dc.subjectepicardial adipose tissue
dc.subjecttype-2 diabetes mellitus.
dc.subject.meshAdipose Tissue
dc.subject.meshAged
dc.subject.meshCoronary Artery Disease
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLipid Metabolism
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPericardium
dc.subject.meshRisk Factors
dc.subject.meshSterol Regulatory Element Binding Protein 1
dc.subject.meshSterol Regulatory Element Binding Protein 2
dc.subject.meshSterols
dc.titleExpression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication

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