Publication:
A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue.

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Date

2019-02-25

Authors

Chitnis, Girish D
Verma, Mohan K S
Lamazouade, Julien
Gonzalez-Andrades, Miguel
Yang, Kisuk
Dergham, Ali
Jones, Peter Anthony
Mead, Benjamin E
Cruzat, Andrea
Tong, Zhixiang

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Nature Publishing Group
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Abstract

The precision of the delivery of therapeutics to the desired injection site by syringes and hollow needles typically depends on the operator. Here, we introduce a highly sensitive, completely mechanical and cost-effective injector for targeting tissue reliably and precisely. As the operator pushes the syringe plunger, the injector senses the loss-of-resistance on encountering a softer tissue or a cavity, stops advancing the needle and delivers the payload. We demonstrate that the injector can reliably deliver liquids to the suprachoroidal space-a challenging injection site that provides access to the back of the eye-for a wide range of eye sizes, scleral thicknesses and intraocular pressures, and target sites relevant for epidural injections, subcutaneous injections and intraperitoneal access. The design of this simple and effective injector can be adapted for a broad variety of clinical applications.

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MeSH Terms

Animals
Drug delivery systems
Equipment design
Eye
Humans
Infusion pumps
Injections
Injections, epidural

DeCS Terms

Bombas de infusión
Diseño de equipo
Inyecciones
Inyecciones epidurales
Ojo
Sistemas de liberación de medicamentos

CIE Terms

Keywords

Injections, intraperitoneal, Injections, subcutaneous, Needles, Rabbits, Syringes, Wounds and injuries

Citation

Chitnis GD, Verma MKS, Lamazouade J, Gonzalez-Andrades M, Yang K, Dergham A, et al. A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue. Nat Biomed Eng. 2019 Aug;3(8):621-631