RT Journal Article
T1 A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue.
A1 Chitnis, Girish D
A1 Verma, Mohan K S
A1 Lamazouade, Julien
A1 Gonzalez-Andrades, Miguel
A1 Yang, Kisuk
A1 Dergham, Ali
A1 Jones, Peter Anthony
A1 Mead, Benjamin E
A1 Cruzat, Andrea
A1 Tong, Zhixiang
A1 Martyn, Keir
A1 Solanki, Aniruddh
A1 Landon-Brace, Natalie
A1 Karp, Jeffrey M
K1 Injections, intraperitoneal
K1 Injections, subcutaneous
K1 Needles
K1 Rabbits
K1 Syringes
K1 Wounds and injuries
AB The precision of the delivery of therapeutics to the desired injection site by syringes and hollow needles typically depends on the operator. Here, we introduce a highly sensitive, completely mechanical and cost-effective injector for targeting tissue reliably and precisely. As the operator pushes the syringe plunger, the injector senses the loss-of-resistance on encountering a softer tissue or a cavity, stops advancing the needle and delivers the payload. We demonstrate that the injector can reliably deliver liquids to the suprachoroidal space-a challenging injection site that provides access to the back of the eye-for a wide range of eye sizes, scleral thicknesses and intraocular pressures, and target sites relevant for epidural injections, subcutaneous injections and intraperitoneal access. The design of this simple and effective injector can be adapted for a broad variety of clinical applications.
PB Nature Publishing Group
YR 2019
FD 2019-02-25
LK http://hdl.handle.net/10668/14376
UL http://hdl.handle.net/10668/14376
LA en
NO Chitnis GD, Verma MKS, Lamazouade J, Gonzalez-Andrades M, Yang K, Dergham A, et al. A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue. Nat Biomed Eng. 2019 Aug;3(8):621-631
NO Funding for this research was provided by the R01HL095722 to JMK. Animal experiments were funded through Boston-KPro research fund to MGA and A.C. We would like to thank Dr. Yookyung Jung and Prof. Charles P. Lin for the use of intravital microscope, H. Greg Lin and Harvard’s Center for Nanoscale Systems for use of microCT system, and Kathleen Cormier and the Hope Babette Tang Histology Facility at the Koch Institute at MIT for performing histology sections
DS RISalud
RD Apr 6, 2025