Publication: Generation of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism.
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2019-05-29
Authors
Garcia-Delgado, Ana B
Calado, Sofia M
Valdes-Sanchez, Lourdes M
Montero-Sanchez, Adoracion
Ponte-Zuñiga, Beatriz
de la Cerda, Berta
Bhattacharya, Shom Shanker
Diaz-Corrales, Francisco J
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Abstract
Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and is characterized by progressive degeneration of the macula, the central region of the retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) from a patient with a clinical diagnosis of dry AMD carrying the CFH Y402H polymorphism. Sendai virus was using for reprogramming and the pluripotent and differentiation capacity of the cells were assessed by immunocytochemistry and RT-PCR.
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MeSH Terms
Aged, 80 and over
Cell Line
Cellular Reprogramming Techniques
Complement Factor H
Female
Humans
Induced Pluripotent Stem Cells
Macular Degeneration
Polymorphism, Genetic
Cell Line
Cellular Reprogramming Techniques
Complement Factor H
Female
Humans
Induced Pluripotent Stem Cells
Macular Degeneration
Polymorphism, Genetic