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Generation of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism.

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dc.contributor.authorGarcia-Delgado, Ana B
dc.contributor.authorCalado, Sofia M
dc.contributor.authorValdes-Sanchez, Lourdes M
dc.contributor.authorMontero-Sanchez, Adoracion
dc.contributor.authorPonte-Zuñiga, Beatriz
dc.contributor.authorde la Cerda, Berta
dc.contributor.authorBhattacharya, Shom Shanker
dc.contributor.authorDiaz-Corrales, Francisco J
dc.date.accessioned2023-01-25T13:34:43Z
dc.date.available2023-01-25T13:34:43Z
dc.date.issued2019-05-29
dc.description.abstractAge-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and is characterized by progressive degeneration of the macula, the central region of the retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) from a patient with a clinical diagnosis of dry AMD carrying the CFH Y402H polymorphism. Sendai virus was using for reprogramming and the pluripotent and differentiation capacity of the cells were assessed by immunocytochemistry and RT-PCR.
dc.identifier.doi10.1016/j.scr.2019.101473
dc.identifier.essn1876-7753
dc.identifier.pmid31176916
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.scr.2019.101473
dc.identifier.urihttp://hdl.handle.net/10668/14092
dc.journal.titleStem cell research
dc.journal.titleabbreviationStem Cell Res
dc.language.isoen
dc.organizationCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER
dc.organizationHospital Universitario Virgen Macarena
dc.page.number101473
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.meshAged, 80 and over
dc.subject.meshCell Line
dc.subject.meshCellular Reprogramming Techniques
dc.subject.meshComplement Factor H
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInduced Pluripotent Stem Cells
dc.subject.meshMacular Degeneration
dc.subject.meshPolymorphism, Genetic
dc.titleGeneration of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number38
dspace.entity.typePublication

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