Publication: Pattern of CNS relapse in acute lymphoblastic leukemia BCR-ABL positive, the importance of characterization of ABL1 mutations in cerebrospinal fluid.
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Identifiers
Date
2016-06
Authors
Sanchez, R
Ayala, R
Alonso, RA
Ribera, J
García, O
Mercadal, S
Montesinos, P
Martino, R
Barba, P
González-Campos, J
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Ferrata Storti Foundation
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Abstract
He incidence of central nervous system (CNS) relapse among; patients with BCR/ABL-positive acute lymphoblastic leukemia (ALL) is 8-17%.
Although tyrosine-kinase inhibitors (TKI), especially imatinib, are included in;
the first-line treatment in these patients, their concentration in CNS is too low;
to effectively prevent CNS relapse, making CNS prophylaxis mandatory.
Aims: To study the frequency, predictors and evolution of BCR-ABL positive;
ALL patients with CNS relapse in two consecutive clinical trials of the PETHEMA;
group using imatinib and chemotherapy. As secondary objective we proposed;
the introduction of a new method for the study of variants of uncertain;
significance (VUS) in kinase domain of the BCR-ABL from cDNA of cerebrospinal;
fluid (CSF) blasts, in order to adapt the TKI used in relapse according;
to the clonal evolution from bone marrow (BM) to CSF cells.
Description
MeSH Terms
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::Nucleic Acid Probes::DNA Probes::DNA, Complementary
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Proto-Oncogene Proteins c-abl::Fusion Proteins, bcr-abl
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Anatomy::Nervous System
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::Nucleic Acid Probes::DNA Probes::DNA, Complementary
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Proto-Oncogene Proteins c-abl::Fusion Proteins, bcr-abl
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Anatomy::Nervous System
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine
DeCS Terms
CIE Terms
Keywords
Médula ósea, Evolución clonal, ADN complementario, Proteínas de fusión bcr-abl, Humanos, Mesilato de imatinib, Incidencia, Masculino, Sistema nervioso, Leucemia-linfoma linfoblástico de células precursoras, Recurrencia, Tirosina
Citation
Sanchez R, Ayala R, Alonso RA, Ribera J, García O, Mercadal S, et al. Pattern of CNS relapse in acute lymphoblastic leukemia BCR-ABL positive, the importance of characterization of ABL1 mutations in cerebrospinal fluid. Haematologica. 2016. 101 (s1) E865