TY - CONF AU - Sanchez, R AU - Ayala, R AU - Alonso, RA AU - Ribera, J AU - García, O AU - Mercadal, S AU - Montesinos, P AU - Martino, R AU - Barba, P AU - González-Campos, J AU - Barrios, M AU - Lavilla, E AU - Gil, C AU - Bernal, T AU - Escoda, L AU - Abella, E AU - Amigo, ML AU - Moreno, MJ AU - Bravo, P AU - Guàrdia, R AU - Hernández-Rivas, JM AU - García-Guiñón, A AU - Piernas, S AU - Ribera, JM AU - Martínez-López, J PY - 2016 SN - 0390-6078 UR - http://hdl.handle.net/10668/2444 T2 - Haematologica AB - He incidence of central nervous system (CNS) relapse among; patients with BCR/ABL-positive acute lymphoblastic leukemia (ALL) is 8-17%. Although tyrosine-kinase inhibitors (TKI), especially imatinib, are included in; the first-line treatment in these... LA - en PB - Ferrata Storti Foundation KW - Médula ósea KW - Evolución clonal KW - ADN complementario KW - Proteínas de fusión bcr-abl KW - Humanos KW - Mesilato de imatinib KW - Incidencia KW - Masculino KW - Sistema nervioso KW - Leucemia-linfoma linfoblástico de células precursoras KW - Recurrencia KW - Tirosina KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::Nucleic Acid Probes::DNA Probes::DNA, Complementary KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Proto-Oncogene Proteins c-abl::Fusion Proteins,... KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Anatomy::Nervous System KW - Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine TI - Pattern of CNS relapse in acute lymphoblastic leukemia BCR-ABL positive, the importance of characterization of ABL1 mutations in cerebrospinal fluid. TY - conference presentation ER -