Publication: Pattern of CNS relapse in acute lymphoblastic leukemia BCR-ABL positive, the importance of characterization of ABL1 mutations in cerebrospinal fluid.
| dc.contributor.author | Sanchez, R | |
| dc.contributor.author | Ayala, R | |
| dc.contributor.author | Alonso, RA | |
| dc.contributor.author | Ribera, J | |
| dc.contributor.author | García, O | |
| dc.contributor.author | Mercadal, S | |
| dc.contributor.author | Montesinos, P | |
| dc.contributor.author | Martino, R | |
| dc.contributor.author | Barba, P | |
| dc.contributor.author | González-Campos, J | |
| dc.contributor.author | Barrios, M | |
| dc.contributor.author | Lavilla, E | |
| dc.contributor.author | Gil, C | |
| dc.contributor.author | Bernal, T | |
| dc.contributor.author | Escoda, L | |
| dc.contributor.author | Abella, E | |
| dc.contributor.author | Amigo, ML | |
| dc.contributor.author | Moreno, MJ | |
| dc.contributor.author | Bravo, P | |
| dc.contributor.author | Guàrdia, R | |
| dc.contributor.author | Hernández-Rivas, JM | |
| dc.contributor.author | García-Guiñón, A | |
| dc.contributor.author | Piernas, S | |
| dc.contributor.author | Ribera, JM | |
| dc.contributor.author | Martínez-López, J | |
| dc.contributor.authoraffiliation | [Sanchez,P] Biología Molecular Hematología. [Ayala,R; Martínez-López,J] Fundación Hospital Universitario 12 de Octubre. [Alonso,RA] Hematología, Hospital Universitario 12 de Octubre, Madrid. [Ribera,J; García,O] ICO-Hospital Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras. [Mercadal,S] ICO- Hospital Duran i Reynals (Bellvitge), Barcelona. [Montesinos,P] Hospital La Fe, Valencia. [Martino,R] Hospital Sant Pau. [Barba,P] Hospital Vall d’Hebron, Barcelona. [González-Campos,J] Hospital Virgen del Rocío, Sevilla. [Barrios,M] Hospital Carlos Haya, Málaga. [Lavilla,E] Hospital Lucus Augusti, Lugo. [Gil,C] Hospital General Universitario de Alicante, Alicante. [Bernal,T] Hospital Central de Asturias, Oviedo. [Escoda,L] Hospital Joan XXIII, Tarragona. [Abella,E] Hospital del Mar, Barcelona. [Amigo,ML] Hospital Meseguer, Murcia. [Moreno,MJ] Hospital Virgen de la Victoria, Málaga. [Bravo,P] Hospital Fuenlabrada, Fuenlabrada (Madrid). [Guàrdia,R] ICO-Hospital Josep Trueta, Girona. [Hernández-Rivas,JM] Hospital Universitario de Salamanca, Salamanca. [García-Guiñón,A] Hospital Arnau de Vilanova, Lleida. [Piernas,S] Hospital Parc Taulí, Sabadell (Barcelona), Spain. | es |
| dc.date.accessioned | 2016-10-03T11:52:48Z | |
| dc.date.available | 2016-10-03T11:52:48Z | |
| dc.date.issued | 2016-06 | |
| dc.description.abstract | He incidence of central nervous system (CNS) relapse among; patients with BCR/ABL-positive acute lymphoblastic leukemia (ALL) is 8-17%. Although tyrosine-kinase inhibitors (TKI), especially imatinib, are included in; the first-line treatment in these patients, their concentration in CNS is too low; to effectively prevent CNS relapse, making CNS prophylaxis mandatory. Aims: To study the frequency, predictors and evolution of BCR-ABL positive; ALL patients with CNS relapse in two consecutive clinical trials of the PETHEMA; group using imatinib and chemotherapy. As secondary objective we proposed; the introduction of a new method for the study of variants of uncertain; significance (VUS) in kinase domain of the BCR-ABL from cDNA of cerebrospinal; fluid (CSF) blasts, in order to adapt the TKI used in relapse according; to the clonal evolution from bone marrow (BM) to CSF cells. | es |
| dc.description.version | No | es |
| dc.identifier.citation | Sanchez R, Ayala R, Alonso RA, Ribera J, García O, Mercadal S, et al. Pattern of CNS relapse in acute lymphoblastic leukemia BCR-ABL positive, the importance of characterization of ABL1 mutations in cerebrospinal fluid. Haematologica. 2016. 101 (s1) E865 | es |
| dc.identifier.essn | 1592-8721 | |
| dc.identifier.issn | 0390-6078 | |
| dc.identifier.uri | http://hdl.handle.net/10668/2444 | |
| dc.journal.title | Haematologica | |
| dc.language.iso | en | |
| dc.publisher | Ferrata Storti Foundation | es |
| dc.relation.publisherversion | http://www.haematologica.org/content/101/s1 | es |
| dc.rights.accessRights | open access | |
| dc.subject | Médula ósea | es |
| dc.subject | Evolución clonal | es |
| dc.subject | ADN complementario | es |
| dc.subject | Proteínas de fusión bcr-abl | es |
| dc.subject | Humanos | es |
| dc.subject | Mesilato de imatinib | es |
| dc.subject | Incidencia | es |
| dc.subject | Masculino | es |
| dc.subject | Sistema nervioso | es |
| dc.subject | Leucemia-linfoma linfoblástico de células precursoras | es |
| dc.subject | Recurrencia | es |
| dc.subject | Tirosina | es |
| dc.subject.mesh | Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow | es |
| dc.subject.mesh | Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::Nucleic Acid Probes::DNA Probes::DNA, Complementary | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Proto-Oncogene Proteins c-abl::Fusion Proteins, bcr-abl | es |
| dc.subject.mesh | Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate | es |
| dc.subject.mesh | Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence | es |
| dc.subject.mesh | Medical Subject Headings::Check Tags::Male | es |
| dc.subject.mesh | Medical Subject Headings::Anatomy::Nervous System | es |
| dc.subject.mesh | Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma | es |
| dc.subject.mesh | Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine | es |
| dc.title | Pattern of CNS relapse in acute lymphoblastic leukemia BCR-ABL positive, the importance of characterization of ABL1 mutations in cerebrospinal fluid. | es |
| dc.type | conference presentation | |
| dc.type.hasVersion | VoR | |
| dspace.entity.type | Publication |
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