Publication:
Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project.

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Date

2021-12-07

Authors

Estevez-Lopez, Fernando
Guerrero-Gonzalez, Juan M
Salazar-Tortosa, Diego
Camiletti-Moiron, Daniel
Gavilan-Carrera, Blanca
Aparicio, Virginia A
Acosta-Manzano, Pedro
Alvarez-Gallardo, Inmaculada C
Segura-Jimenez, Víctor
Soriano-Maldonado, Alberto

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Oxford University Press
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It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene-gene, gene-PA and gene-sedentary behaviour interactions with pain and pain-related cognitions in women with FM. Saliva samples from 274 women with FM [mean (s.d.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor μ gene, OPRM1) was related to pain catastrophizing. Five gene-behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032). The HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene-sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain.

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MeSH Terms

Catechol O-Methyltransferase
Female
Fibromyalgia
Genetic Predisposition to Disease
Genotype
Humans
Life Style
Middle Aged
NAV1.7 Voltage-Gated Sodium Channel
Pain
Polymorphism, Single Nucleotide

DeCS Terms

Canal de sodio activado por voltaje NAV1.7
Catecol O-Metiltransferasa
Estilo de vida
Femenino
Fibromialgia
Genotipo
Pan
Polimorfismo de nucleótido simple
Predisposición genética a la enfermedad
Persona de mediana edad
Humanos

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Keywords

5-hydroxytryptamine receptor 2A gene, adrenoceptor alpha 1A gene, charged multivesicular body protein 1A gene, opioid receptor μ1 gene, sodium voltage-gated channel alpha subunit 9 gene

Citation

Estévez-López F, Guerrero-González JM, Salazar-Tortosa D, Camiletti-Moirón D, Gavilán-Carrera B, Aparicio VA, et al. Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project. Rheumatology (Oxford). 2022 Aug 3;61(8):3180-3191.