Publication:
Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project.

dc.contributor.authorEstevez-Lopez, Fernando
dc.contributor.authorGuerrero-Gonzalez, Juan M
dc.contributor.authorSalazar-Tortosa, Diego
dc.contributor.authorCamiletti-Moiron, Daniel
dc.contributor.authorGavilan-Carrera, Blanca
dc.contributor.authorAparicio, Virginia A
dc.contributor.authorAcosta-Manzano, Pedro
dc.contributor.authorAlvarez-Gallardo, Inmaculada C
dc.contributor.authorSegura-Jimenez, Víctor
dc.contributor.authorSoriano-Maldonado, Alberto
dc.contributor.authorGeenen, Rinie
dc.contributor.authorDelgado-Fernandez, Manuel
dc.contributor.authorMartinez-Gonzalez, Luis J
dc.contributor.authorRuiz, Jonatan R
dc.contributor.authorAlvarez-Cubero, María J
dc.contributor.funderSpanish Ministry of Economy and Competitiveness
dc.contributor.funderpanish Ministry of Education
dc.contributor.funderConsejería de Turismo, Comercio y Deporte, Junta de Andalucía
dc.contributor.funderConsejería de Salud, Junta de Andalucía
dc.contributor.funderUniversity of Granada, Plan Propio de Investigación 2016
dc.date.accessioned2023-05-03T13:27:53Z
dc.date.available2023-05-03T13:27:53Z
dc.date.issued2021-12-07
dc.description.abstractIt is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene-gene, gene-PA and gene-sedentary behaviour interactions with pain and pain-related cognitions in women with FM. Saliva samples from 274 women with FM [mean (s.d.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor μ gene, OPRM1) was related to pain catastrophizing. Five gene-behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032). The HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene-sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain.
dc.identifier.citationEstévez-López F, Guerrero-González JM, Salazar-Tortosa D, Camiletti-Moirón D, Gavilán-Carrera B, Aparicio VA, et al. Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project. Rheumatology (Oxford). 2022 Aug 3;61(8):3180-3191.
dc.identifier.doi10.1093/rheumatology/keab911
dc.identifier.essn1462-0332
dc.identifier.pmcPMC9348776
dc.identifier.pmid34875034
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348776/pdf
dc.identifier.unpaywallURLhttps://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keab911/42816533/keab911.pdf
dc.identifier.urihttp://hdl.handle.net/10668/19833
dc.issue.number8
dc.journal.titleRheumatology (Oxford, England)
dc.journal.titleabbreviationRheumatology (Oxford)
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number3180-3191
dc.provenanceRealizada la curación de contenido 20/08/2024
dc.publisherOxford University Press
dc.pubmedtypeJournal Article
dc.pubmedtypeMeta-Analysis
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDI + D+i DEP2010-15639
dc.relation.projectID I+ D+i DEP2013-40908-R
dc.relation.projectIDBES-2014-067612
dc.relation.projectIDFPU13/03410
dc.relation.projectIDFPU15/0002
dc.relation.projectIDCTCD-201000019242
dc.relation.projectID(PI-0520-2016
dc.relation.publisherversionhttps://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/keab911
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject5-hydroxytryptamine receptor 2A gene
dc.subjectadrenoceptor alpha 1A gene
dc.subjectcharged multivesicular body protein 1A gene
dc.subjectopioid receptor μ1 gene
dc.subjectsodium voltage-gated channel alpha subunit 9 gene
dc.subject.decsCanal de sodio activado por voltaje NAV1.7
dc.subject.decsCatecol O-Metiltransferasa
dc.subject.decsEstilo de vida
dc.subject.decsFemenino
dc.subject.decsFibromialgia
dc.subject.decsGenotipo
dc.subject.decsPan
dc.subject.decsPolimorfismo de nucleótido simple
dc.subject.decsPredisposición genética a la enfermedad
dc.subject.decsPersona de mediana edad
dc.subject.decsHumanos
dc.subject.meshCatechol O-Methyltransferase
dc.subject.meshFemale
dc.subject.meshFibromyalgia
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshLife Style
dc.subject.meshMiddle Aged
dc.subject.meshNAV1.7 Voltage-Gated Sodium Channel
dc.subject.meshPain
dc.subject.meshPolymorphism, Single Nucleotide
dc.titleInterplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number61
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
PMC9348776.pdf
Size:
653.37 KB
Format:
Adobe Portable Document Format
No Thumbnail Available
Name:
Estevez_InterplayBetween_MaterialSuplementario.docx
Size:
177.61 KB
Format:
Microsoft Word XML