RT Journal Article T1 Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project. A1 Estevez-Lopez, Fernando A1 Guerrero-Gonzalez, Juan M A1 Salazar-Tortosa, Diego A1 Camiletti-Moiron, Daniel A1 Gavilan-Carrera, Blanca A1 Aparicio, Virginia A A1 Acosta-Manzano, Pedro A1 Alvarez-Gallardo, Inmaculada C A1 Segura-Jimenez, Víctor A1 Soriano-Maldonado, Alberto A1 Geenen, Rinie A1 Delgado-Fernandez, Manuel A1 Martinez-Gonzalez, Luis J A1 Ruiz, Jonatan R A1 Alvarez-Cubero, María J K1 5-hydroxytryptamine receptor 2A gene K1 adrenoceptor alpha 1A gene K1 charged multivesicular body protein 1A gene K1 opioid receptor μ1 gene K1 sodium voltage-gated channel alpha subunit 9 gene AB It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene-gene, gene-PA and gene-sedentary behaviour interactions with pain and pain-related cognitions in women with FM. Saliva samples from 274 women with FM [mean (s.d.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor μ gene, OPRM1) was related to pain catastrophizing. Five gene-behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032). The HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene-sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain. PB Oxford University Press YR 2021 FD 2021-12-07 LK http://hdl.handle.net/10668/19833 UL http://hdl.handle.net/10668/19833 LA en NO Estévez-López F, Guerrero-González JM, Salazar-Tortosa D, Camiletti-Moirón D, Gavilán-Carrera B, Aparicio VA, et al. Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project. Rheumatology (Oxford). 2022 Aug 3;61(8):3180-3191. DS RISalud RD Apr 6, 2025