Publication:
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations

No Thumbnail Available

Date

2016-12-06

Authors

Blanco, Gonzalo
Puiggros, Anna
Baliakas, Panagiotis
Athanasiadou, Anastasia
Garcia-Malo, MaDolores
Collado, Rosa
Xochelli, Aliki
Rodriguez-Rivera, Maria
Ortega, Margarita
Jose Calasanz, Ma

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Impact journals llc
Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P = 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.

Description

MeSH Terms

DeCS Terms

CIE Terms

Keywords

17p deletion, Cll, Mutations, Cytogenetics, Progression, Guidelines, Diagnosis, Predicts, Genes, Fish

Citation