%0 Journal Article
%A Blanco, Gonzalo
%A Puiggros, Anna
%A Baliakas, Panagiotis
%A Athanasiadou, Anastasia
%A Garcia-Malo, MaDolores
%A Collado, Rosa
%A Xochelli, Aliki
%A Rodriguez-Rivera, Maria
%A Ortega, Margarita
%A Jose Calasanz, Ma
%A Luno, Elisa
%A Vargas, MaTeresa
%A Grau, Javier
%A Martinez-Laperche, Carolina
%A Valiente, Alberto
%A Cervera, Jose
%A Anagnostopoulos, Achilles
%A Gimeno, Eva
%A Abella, Eugenia
%A Stalika, Evangelia
%A Ma Hernandez-Rivas, Jesus
%A Jose Ortuno, Francisco
%A Robles, Diego
%A Ferrer, Ana
%A Ivars, David
%A Gonzalez, Marcos
%A Bosch, Francesc
%A Abrisqueta, Pau
%A Stamatopoulos, Kostas
%A Espinet, Blanca
%T Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations
%D 2016
%U http://hdl.handle.net/10668/19441
%X Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P = 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.
%K 17p deletion
%K Cll
%K Mutations
%K Cytogenetics
%K Progression
%K Guidelines
%K Diagnosis
%K Predicts
%K Genes
%K Fish
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