RT Journal Article
T1 Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations
A1 Blanco, Gonzalo
A1 Puiggros, Anna
A1 Baliakas, Panagiotis
A1 Athanasiadou, Anastasia
A1 Garcia-Malo, MaDolores
A1 Collado, Rosa
A1 Xochelli, Aliki
A1 Rodriguez-Rivera, Maria
A1 Ortega, Margarita
A1 Jose Calasanz, Ma
A1 Luno, Elisa
A1 Vargas, MaTeresa
A1 Grau, Javier
A1 Martinez-Laperche, Carolina
A1 Valiente, Alberto
A1 Cervera, Jose
A1 Anagnostopoulos, Achilles
A1 Gimeno, Eva
A1 Abella, Eugenia
A1 Stalika, Evangelia
A1 Ma Hernandez-Rivas, Jesus
A1 Jose Ortuno, Francisco
A1 Robles, Diego
A1 Ferrer, Ana
A1 Ivars, David
A1 Gonzalez, Marcos
A1 Bosch, Francesc
A1 Abrisqueta, Pau
A1 Stamatopoulos, Kostas
A1 Espinet, Blanca
K1 17p deletion
K1 Cll
K1 Mutations
K1 Cytogenetics
K1 Progression
K1 Guidelines
K1 Diagnosis
K1 Predicts
K1 Genes
K1 Fish
AB Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P = 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.
PB Impact journals llc
YR 2016
FD 2016-12-06
LK http://hdl.handle.net/10668/19441
UL http://hdl.handle.net/10668/19441
LA en
DS RISalud
RD Apr 11, 2025