Publication: Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study.
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Identifiers
Date
2019-06-24
Authors
Angarita Davila, Lisse
Bermudez, Valmore
Aparicio, Daniel
Cespedes, Virginia
Escobar, Ma Cristina
Duran-Agüero, Samuel
Cisternas, Silvana
de Assis Costa, Jorge
Rojas-Gomez, Diana
Reyna, Nadia
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p< 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt
may have influenced these factors.
Description
MeSH Terms
Administration, oral
Appetite regulation
Biomarkers
Blood glucose
Cross-over studies
Diabetes mellitus, type 2
Dietary supplements
Disaccharides
Double-blind method
Female
Fructose
Gastric inhibitory polypeptide
Glucagon-like peptide 1
Glycemic index
Humans
Insulin
Isomaltose
Male
Middle aged
Peptide hormones
Time factors
Treatment outcome
Appetite regulation
Biomarkers
Blood glucose
Cross-over studies
Diabetes mellitus, type 2
Dietary supplements
Disaccharides
Double-blind method
Female
Fructose
Gastric inhibitory polypeptide
Glucagon-like peptide 1
Glycemic index
Humans
Insulin
Isomaltose
Male
Middle aged
Peptide hormones
Time factors
Treatment outcome
DeCS Terms
Administración oral
Diabetes mellitus tipo 2
Disacáridos
Estudios cruzados
Fructosa
Glucemia
Hormonas peptídicas
Insulina
Isomaltosa
Diabetes mellitus tipo 2
Disacáridos
Estudios cruzados
Fructosa
Glucemia
Hormonas peptídicas
Insulina
Isomaltosa
CIE Terms
Keywords
Glycaemic index, Incretins, Isomaltulose, Nutritional supplement, Subjective appetite, Sucromalt
Citation
Angarita Dávila L, Bermúdez V, Aparicio D, Céspedes V, Escobar MC, Durán-Agüero S, et al. Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study. Nutrients. 2019 Jun 28;11(7):1477