%0 Journal Article
%A Angarita Davila, Lisse
%A Bermudez, Valmore
%A Aparicio, Daniel
%A Cespedes, Virginia
%A Escobar, Ma Cristina
%A Duran-Agüero, Samuel
%A Cisternas, Silvana
%A de Assis Costa, Jorge
%A Rojas-Gomez, Diana
%A Reyna, Nadia
%A Lopez-Miranda, Jose
%T Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study.
%D 2019
%U http://hdl.handle.net/10668/14202
%X Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p< 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromaltmay have influenced these factors.
%K Glycaemic index
%K Incretins
%K Isomaltulose
%K Nutritional supplement
%K Subjective appetite
%K Sucromalt
%~