Publication: Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study.
dc.contributor.author | Angarita Davila, Lisse | |
dc.contributor.author | Bermudez, Valmore | |
dc.contributor.author | Aparicio, Daniel | |
dc.contributor.author | Cespedes, Virginia | |
dc.contributor.author | Escobar, Ma Cristina | |
dc.contributor.author | Duran-Agüero, Samuel | |
dc.contributor.author | Cisternas, Silvana | |
dc.contributor.author | de Assis Costa, Jorge | |
dc.contributor.author | Rojas-Gomez, Diana | |
dc.contributor.author | Reyna, Nadia | |
dc.contributor.author | Lopez-Miranda, Jose | |
dc.date.accessioned | 2023-01-25T13:36:08Z | |
dc.date.available | 2023-01-25T13:36:08Z | |
dc.date.issued | 2019-06-24 | |
dc.description.abstract | Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p< 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors. | |
dc.description.version | Si | |
dc.identifier.citation | Angarita Dávila L, Bermúdez V, Aparicio D, Céspedes V, Escobar MC, Durán-Agüero S, et al. Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study. Nutrients. 2019 Jun 28;11(7):1477 | |
dc.identifier.doi | 10.3390/nu11071477 | |
dc.identifier.essn | 2072-6643 | |
dc.identifier.pmc | PMC6683048 | |
dc.identifier.pmid | 31261732 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683048/pdf | |
dc.identifier.unpaywallURL | https://res.mdpi.com/d_attachment/nutrients/nutrients-11-01477/article_deploy/nutrients-11-01477-v2.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/14202 | |
dc.issue.number | 7 | |
dc.journal.title | Nutrients | |
dc.journal.titleabbreviation | Nutrients | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Reina Sofía | |
dc.organization | Instituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC | |
dc.page.number | 23 | |
dc.provenance | Realizada la curación de contenido 08/08/2024 | |
dc.publisher | MDPI | |
dc.pubmedtype | Comparative Study | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Randomized Controlled Trial | |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/11/7/1477 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Glycaemic index | |
dc.subject | Incretins | |
dc.subject | Isomaltulose | |
dc.subject | Nutritional supplement | |
dc.subject | Subjective appetite | |
dc.subject | Sucromalt | |
dc.subject.decs | Administración oral | |
dc.subject.decs | Diabetes mellitus tipo 2 | |
dc.subject.decs | Disacáridos | |
dc.subject.decs | Estudios cruzados | |
dc.subject.decs | Fructosa | |
dc.subject.decs | Glucemia | |
dc.subject.decs | Hormonas peptídicas | |
dc.subject.decs | Insulina | |
dc.subject.decs | Isomaltosa | |
dc.subject.mesh | Administration, oral | |
dc.subject.mesh | Appetite regulation | |
dc.subject.mesh | Biomarkers | |
dc.subject.mesh | Blood glucose | |
dc.subject.mesh | Cross-over studies | |
dc.subject.mesh | Diabetes mellitus, type 2 | |
dc.subject.mesh | Dietary supplements | |
dc.subject.mesh | Disaccharides | |
dc.subject.mesh | Double-blind method | |
dc.subject.mesh | Female | |
dc.subject.mesh | Fructose | |
dc.subject.mesh | Gastric inhibitory polypeptide | |
dc.subject.mesh | Glucagon-like peptide 1 | |
dc.subject.mesh | Glycemic index | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Insulin | |
dc.subject.mesh | Isomaltose | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle aged | |
dc.subject.mesh | Peptide hormones | |
dc.subject.mesh | Time factors | |
dc.subject.mesh | Treatment outcome | |
dc.title | Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 11 | |
dspace.entity.type | Publication |