Publication:
Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study.

dc.contributor.authorAngarita Davila, Lisse
dc.contributor.authorBermudez, Valmore
dc.contributor.authorAparicio, Daniel
dc.contributor.authorCespedes, Virginia
dc.contributor.authorEscobar, Ma Cristina
dc.contributor.authorDuran-Agüero, Samuel
dc.contributor.authorCisternas, Silvana
dc.contributor.authorde Assis Costa, Jorge
dc.contributor.authorRojas-Gomez, Diana
dc.contributor.authorReyna, Nadia
dc.contributor.authorLopez-Miranda, Jose
dc.date.accessioned2023-01-25T13:36:08Z
dc.date.available2023-01-25T13:36:08Z
dc.date.issued2019-06-24
dc.description.abstractOral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p< 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.
dc.description.versionSi
dc.identifier.citationAngarita Dávila L, Bermúdez V, Aparicio D, Céspedes V, Escobar MC, Durán-Agüero S, et al. Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study. Nutrients. 2019 Jun 28;11(7):1477
dc.identifier.doi10.3390/nu11071477
dc.identifier.essn2072-6643
dc.identifier.pmcPMC6683048
dc.identifier.pmid31261732
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683048/pdf
dc.identifier.unpaywallURLhttps://res.mdpi.com/d_attachment/nutrients/nutrients-11-01477/article_deploy/nutrients-11-01477-v2.pdf
dc.identifier.urihttp://hdl.handle.net/10668/14202
dc.issue.number7
dc.journal.titleNutrients
dc.journal.titleabbreviationNutrients
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.page.number23
dc.provenanceRealizada la curación de contenido 08/08/2024
dc.publisherMDPI
dc.pubmedtypeComparative Study
dc.pubmedtypeJournal Article
dc.pubmedtypeRandomized Controlled Trial
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/11/7/1477
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGlycaemic index
dc.subjectIncretins
dc.subjectIsomaltulose
dc.subjectNutritional supplement
dc.subjectSubjective appetite
dc.subjectSucromalt
dc.subject.decsAdministración oral
dc.subject.decsDiabetes mellitus tipo 2
dc.subject.decsDisacáridos
dc.subject.decsEstudios cruzados
dc.subject.decsFructosa
dc.subject.decsGlucemia
dc.subject.decsHormonas peptídicas
dc.subject.decsInsulina
dc.subject.decsIsomaltosa
dc.subject.meshAdministration, oral
dc.subject.meshAppetite regulation
dc.subject.meshBiomarkers
dc.subject.meshBlood glucose
dc.subject.meshCross-over studies
dc.subject.meshDiabetes mellitus, type 2
dc.subject.meshDietary supplements
dc.subject.meshDisaccharides
dc.subject.meshDouble-blind method
dc.subject.meshFemale
dc.subject.meshFructose
dc.subject.meshGastric inhibitory polypeptide
dc.subject.meshGlucagon-like peptide 1
dc.subject.meshGlycemic index
dc.subject.meshHumans
dc.subject.meshInsulin
dc.subject.meshIsomaltose
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshPeptide hormones
dc.subject.meshTime factors
dc.subject.meshTreatment outcome
dc.titleEffect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication

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