Publication:
Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.

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Date

2022-11-07

Authors

Mancebo-Perez, Cristina
Vidal, Marta
Aguilar, Ruth
Barrios, Diana
Bardaji, Azucena
Ome-Kaius, Maria
Menendez, Clara
Rogerson, Stephen J
Dobaño, Carlota
Moncunill, Gemma

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BioMed Central Ltd.
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Abstract

Eotaxin-1 concentrations in plasma have been inversely associated with malaria exposure, malaria infection and pregnancy, but the effect of these conditions on the levels of the related chemokines eotaxin-2 and eotaxin-3 remains unknown. Eotaxin-2 and -3 concentrations were measured in 310 peripheral or placental plasma samples from pregnant and non-pregnant individuals from Papua New Guinea (malaria-endemic country) and Spain (malaria-naïve individuals) with previous data on eotaxin-1 concentrations. Correlations between eotaxin concentrations were examined with the Spearman's test. Differences in eotaxin concentrations among groups were evaluated with the Kruskal-Wallis or Mann Whitney tests. The pairwise Wilcoxon test was performed to compare eotaxin-2 concentration between peripheral and placental matched plasmas. Univariable and multivariable linear regression models were estimated to assess the association between eotaxins and Plasmodium infection or gestational age. Eotaxin-2 concentrations in plasma showed a weak positive correlation with eotaxin-3 (rho = 0.35, p  Although a clear epidemiological negative association is observed between eotaxins concentrations and malaria exposure and/or infection, pregnancy may alter this association for eotaxin-2. Further research is required to understand the role of these chemokines in this disease and in combination with pregnancy.

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MeSH Terms

Female
Humans
Pregnancy
Chemokine CCL11
Chemokine CCL24
Chemokine CCL26
Immunoglobulin G
Malaria
Malaria, Falciparum
Placenta
Plasmodium falciparum
Pregnancy Complications, Infectious
Pregnancy Complications, Parasitic

DeCS Terms

Complicaciones infecciosas del embarazo
Complicaciones parasitarias del embarazo
Embarazo
Femenino
Humanos
Inmunoglobulina G
Malaria
Malaria falciparum
Placenta
Plasmodium falciparum
Quimiocina CCL11
Quimiocina CCL24
Quimiocina CCL26

CIE Terms

Keywords

Chemokine, Eotaxin, Malaria, Placenta, Pregnancy

Citation

Mancebo-Pérez C, Vidal M, Aguilar R, Barrios D, Bardají A, Ome-Kaius M, et al. Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy. Malar J. 2022 Nov 15;21(1):336.