Publication: Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
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Identifiers
Date
2022-11-07
Authors
Mancebo-Perez, Cristina
Vidal, Marta
Aguilar, Ruth
Barrios, Diana
Bardaji, Azucena
Ome-Kaius, Maria
Menendez, Clara
Rogerson, Stephen J
Dobaño, Carlota
Moncunill, Gemma
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central Ltd.
Abstract
Eotaxin-1 concentrations in plasma have been inversely associated with malaria exposure, malaria infection and pregnancy, but the effect of these conditions on the levels of the related chemokines eotaxin-2 and eotaxin-3 remains unknown. Eotaxin-2 and -3 concentrations were measured in 310 peripheral or placental plasma samples from pregnant and non-pregnant individuals from Papua New Guinea (malaria-endemic country) and Spain (malaria-naïve individuals) with previous data on eotaxin-1 concentrations. Correlations between eotaxin concentrations were examined with the Spearman's test. Differences in eotaxin concentrations among groups were evaluated with the Kruskal-Wallis or Mann Whitney tests. The pairwise Wilcoxon test was performed to compare eotaxin-2 concentration between peripheral and placental matched plasmas. Univariable and multivariable linear regression models were estimated to assess the association between eotaxins and Plasmodium infection or gestational age. Eotaxin-2 concentrations in plasma showed a weak positive correlation with eotaxin-3 (rho = 0.35, p Although a clear epidemiological negative association is observed between eotaxins concentrations and malaria exposure and/or infection, pregnancy may alter this association for eotaxin-2. Further research is required to understand the role of these chemokines in this disease and in combination with pregnancy.
Description
MeSH Terms
Female
Humans
Pregnancy
Chemokine CCL11
Chemokine CCL24
Chemokine CCL26
Immunoglobulin G
Malaria
Malaria, Falciparum
Placenta
Plasmodium falciparum
Pregnancy Complications, Infectious
Pregnancy Complications, Parasitic
Humans
Pregnancy
Chemokine CCL11
Chemokine CCL24
Chemokine CCL26
Immunoglobulin G
Malaria
Malaria, Falciparum
Placenta
Plasmodium falciparum
Pregnancy Complications, Infectious
Pregnancy Complications, Parasitic
DeCS Terms
Complicaciones infecciosas del embarazo
Complicaciones parasitarias del embarazo
Embarazo
Femenino
Humanos
Inmunoglobulina G
Malaria
Malaria falciparum
Placenta
Plasmodium falciparum
Quimiocina CCL11
Quimiocina CCL24
Quimiocina CCL26
Complicaciones parasitarias del embarazo
Embarazo
Femenino
Humanos
Inmunoglobulina G
Malaria
Malaria falciparum
Placenta
Plasmodium falciparum
Quimiocina CCL11
Quimiocina CCL24
Quimiocina CCL26
CIE Terms
Keywords
Chemokine, Eotaxin, Malaria, Placenta, Pregnancy
Citation
Mancebo-Pérez C, Vidal M, Aguilar R, Barrios D, Bardají A, Ome-Kaius M, et al. Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy. Malar J. 2022 Nov 15;21(1):336.