%0 Journal Article
%A Mancebo-Perez, Cristina
%A Vidal, Marta
%A Aguilar, Ruth
%A Barrios, Diana
%A Bardaji, Azucena
%A Ome-Kaius, Maria
%A Menendez, Clara
%A Rogerson, Stephen J
%A Dobaño, Carlota
%A Moncunill, Gemma
%A Requena, Pilar
%T Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
%D 2022
%U http://hdl.handle.net/10668/20321
%X Eotaxin-1 concentrations in plasma have been inversely associated with malaria exposure, malaria infection and pregnancy, but the effect of these conditions on the levels of the related chemokines eotaxin-2 and eotaxin-3 remains unknown. Eotaxin-2 and -3 concentrations were measured in 310 peripheral or placental plasma samples from pregnant and non-pregnant individuals from Papua New Guinea (malaria-endemic country) and Spain (malaria-naïve individuals) with previous data on eotaxin-1 concentrations. Correlations between eotaxin concentrations were examined with the Spearman's test. Differences in eotaxin concentrations among groups were evaluated with the Kruskal-Wallis or Mann Whitney tests. The pairwise Wilcoxon test was performed to compare eotaxin-2 concentration between peripheral and placental matched plasmas. Univariable and multivariable linear regression models were estimated to assess the association between eotaxins and Plasmodium infection or gestational age. Eotaxin-2 concentrations in plasma showed a weak positive correlation with eotaxin-3 (rho = 0.35, p  Although a clear epidemiological negative association is observed between eotaxins concentrations and malaria exposure and/or infection, pregnancy may alter this association for eotaxin-2. Further research is required to understand the role of these chemokines in this disease and in combination with pregnancy.
%K Chemokine
%K Eotaxin
%K Malaria
%K Placenta
%K Pregnancy
%~