RT Journal Article
T1 Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
A1 Mancebo-Perez, Cristina
A1 Vidal, Marta
A1 Aguilar, Ruth
A1 Barrios, Diana
A1 Bardaji, Azucena
A1 Ome-Kaius, Maria
A1 Menendez, Clara
A1 Rogerson, Stephen J
A1 Dobaño, Carlota
A1 Moncunill, Gemma
A1 Requena, Pilar
K1 Chemokine
K1 Eotaxin
K1 Malaria
K1 Placenta
K1 Pregnancy
AB Eotaxin-1 concentrations in plasma have been inversely associated with malaria exposure, malaria infection and pregnancy, but the effect of these conditions on the levels of the related chemokines eotaxin-2 and eotaxin-3 remains unknown. Eotaxin-2 and -3 concentrations were measured in 310 peripheral or placental plasma samples from pregnant and non-pregnant individuals from Papua New Guinea (malaria-endemic country) and Spain (malaria-naïve individuals) with previous data on eotaxin-1 concentrations. Correlations between eotaxin concentrations were examined with the Spearman's test. Differences in eotaxin concentrations among groups were evaluated with the Kruskal-Wallis or Mann Whitney tests. The pairwise Wilcoxon test was performed to compare eotaxin-2 concentration between peripheral and placental matched plasmas. Univariable and multivariable linear regression models were estimated to assess the association between eotaxins and Plasmodium infection or gestational age. Eotaxin-2 concentrations in plasma showed a weak positive correlation with eotaxin-3 (rho = 0.35, p  Although a clear epidemiological negative association is observed between eotaxins concentrations and malaria exposure and/or infection, pregnancy may alter this association for eotaxin-2. Further research is required to understand the role of these chemokines in this disease and in combination with pregnancy.
PB BioMed Central Ltd.
YR 2022
FD 2022-11-07
LK http://hdl.handle.net/10668/20321
UL http://hdl.handle.net/10668/20321
LA en
NO Mancebo-Pérez C, Vidal M, Aguilar R, Barrios D, Bardají A, Ome-Kaius M, et al. Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy. Malar J. 2022 Nov 15;21(1):336.
DS RISalud
RD Apr 5, 2025