Publication: Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes.
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2016-10-05
Authors
Tulipani, Sara
Palau-Rodriguez, Magali
Miñarro Alonso, Antonio
Cardona, Fernando
Marco-Ramell, Anna
Zonja, Bozo
Lopez de Alda, Miren
Muñoz-Garach, Araceli
Sanchez-Pla, Alejandro
Tinahones, Francisco J
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Abstract
Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, p
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MeSH Terms
Adult
Biomarkers
Diabetes Mellitus, Type 2
Female
Humans
Male
Metabolomics
Middle Aged
Obesity, Morbid
Phenotype
Prediabetic State
Biomarkers
Diabetes Mellitus, Type 2
Female
Humans
Male
Metabolomics
Middle Aged
Obesity, Morbid
Phenotype
Prediabetic State
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Keywords
mass spectrometry, metabolic markers, obesity, observational study, prediabetes