RT Journal Article
T1 Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes.
A1 Tulipani, Sara
A1 Palau-Rodriguez, Magali
A1 Miñarro Alonso, Antonio
A1 Cardona, Fernando
A1 Marco-Ramell, Anna
A1 Zonja, Bozo
A1 Lopez de Alda, Miren
A1 Muñoz-Garach, Araceli
A1 Sanchez-Pla, Alejandro
A1 Tinahones, Francisco J
A1 Andres-Lacueva, Cristina
K1 mass spectrometry
K1 metabolic markers
K1 obesity
K1 observational study
K1 prediabetes
AB Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, p
YR 2016
FD 2016-10-05
LK http://hdl.handle.net/10668/10521
UL http://hdl.handle.net/10668/10521
LA en
DS RISalud
RD Apr 8, 2025