%0 Journal Article
%A Tulipani, Sara
%A Palau-Rodriguez, Magali
%A Miñarro Alonso, Antonio
%A Cardona, Fernando
%A Marco-Ramell, Anna
%A Zonja, Bozo
%A Lopez de Alda, Miren
%A Muñoz-Garach, Araceli
%A Sanchez-Pla, Alejandro
%A Tinahones, Francisco J
%A Andres-Lacueva, Cristina
%T Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes.
%D 2016
%U http://hdl.handle.net/10668/10521
%X Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, p
%K mass spectrometry
%K metabolic markers
%K obesity
%K observational study
%K prediabetes
%~