Publication:
Effect of Vitamin D on Graft-versus-Host Disease.

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Date

2022-04-24

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Rodríguez-Gil, Alfonso
Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez-Simón, José A

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The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.

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calcifediol, calcitriol, graft-versus-host disease, vitamin D, vitamin D receptor (VDR)

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