RT Journal Article
T1 Effect of Vitamin D on Graft-versus-Host Disease.
A1 Rodríguez-Gil, Alfonso
A1 Carrillo-Cruz, Estrella
A1 Marrero-Cepeda, Cristina
A1 Rodríguez, Guillermo
A1 Pérez-Simón, José A
K1 calcifediol
K1 calcitriol
K1 graft-versus-host disease
K1 vitamin D
K1 vitamin D receptor (VDR)
AB The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.
SN 2227-9059
YR 2022
FD 2022-04-24
LK http://hdl.handle.net/10668/20827
UL http://hdl.handle.net/10668/20827
LA en
DS RISalud
RD Apr 12, 2025