%0 Journal Article
%A Rodríguez-Gil, Alfonso
%A Carrillo-Cruz, Estrella
%A Marrero-Cepeda, Cristina
%A Rodríguez, Guillermo
%A Pérez-Simón, José A
%T Effect of Vitamin D on Graft-versus-Host Disease.
%D 2022
%@ 2227-9059
%U http://hdl.handle.net/10668/20827
%X The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.
%K calcifediol
%K calcitriol
%K graft-versus-host disease
%K vitamin D
%K vitamin D receptor (VDR)
%~