Publication: Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
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Identifiers
Date
2020-04-24
Authors
Ortega, Pedro
García-Pichardo, Desiré
San Martin-Alonso, Marta
Rondón, Ana G.
Gómez-González, Belén
Aguilera, Andrés
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Shared Science Publishers
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Abstract
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage can result in genetic alterations and subsequent development of cancer and other genetic diseases. Here, we identified two mutations in conserved residues of histone H3 and histone H4 (H3E73Q and H4E53A) that increase recombinogenic DNA damage. Our results suggest that the accumulation of DNA damage in these histone mutants is largely independent on transcription and might arise as a consequence of problems occurring during DNA replication. This study uncovers the relevance of H3E73 and H4E53 residues in the protection of genome integrity.
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MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histones
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replication
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Chromosome Structures::Chromatin
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replication
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Chromosome Structures::Chromatin
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CIE Terms
Keywords
Chromatin, DNA replication, Recombination, Histone mutants, Cromatina, Replicación del ADN, Recombinación genética, Histonas, Mutación
Citation
Ortega P, García-Pichardo D, San Martin-Alonso M, Rondón AG, Gómez-González B, Aguilera A. Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microb Cell. 2020 Apr 24;7(7):190-198.