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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage

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dc.contributor.authorOrtega, Pedro
dc.contributor.authorGarcía-Pichardo, Desiré
dc.contributor.authorSan Martin-Alonso, Marta
dc.contributor.authorRondón, Ana G.
dc.contributor.authorGómez-González, Belén
dc.contributor.authorAguilera, Andrés
dc.contributor.authoraffiliation[Ortega,P; García-Pichardo,D; San Martin-Alonso,M; Rondón, AG; Gómez-González,B; Aguilera,A] Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.
dc.contributor.funderResearch was supported by the Euro-pean Research Council (ERC2014 AdG669898 TARLOOP), the Spanish Ministry of Economy and Competitiveness (BFU2016-75058-P), the Foundation Vencer el Cáncer and the European Union (FEDER). P. O. was supported by a predoctoral training grant from the Spanish Ministry of Economy and Competitiveness and B.G.-G. by the Span-ish Association Against Cancer (AECC).
dc.date.accessioned2022-04-26T09:59:38Z
dc.date.available2022-04-26T09:59:38Z
dc.date.issued2020-04-24
dc.description.abstractThe stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage can result in genetic alterations and subsequent development of cancer and other genetic diseases. Here, we identified two mutations in conserved residues of histone H3 and histone H4 (H3E73Q and H4E53A) that increase recombinogenic DNA damage. Our results suggest that the accumulation of DNA damage in these histone mutants is largely independent on transcription and might arise as a consequence of problems occurring during DNA replication. This study uncovers the relevance of H3E73 and H4E53 residues in the protection of genome integrity.es_ES
dc.description.versionYeses_ES
dc.identifier.citationOrtega P, García-Pichardo D, San Martin-Alonso M, Rondón AG, Gómez-González B, Aguilera A. Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microb Cell. 2020 Apr 24;7(7):190-198.es_ES
dc.identifier.doi10.15698/mic2020.07.723es_ES
dc.identifier.essn2311-2638
dc.identifier.pmcPMC7328676
dc.identifier.pmid32656258es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3568
dc.journal.titleMicrobial Cell
dc.language.isoen
dc.page.number9 p.
dc.publisherShared Science Publisherses_ES
dc.relation.publisherversionhttp://microbialcell.com/researcharticles/2020a-ortega-microbial-cell/es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectChromatines_ES
dc.subjectDNA replicationes_ES
dc.subjectRecombinationes_ES
dc.subjectHistone mutantses_ES
dc.subjectCromatinaes_ES
dc.subjectReplicación del ADNes_ES
dc.subjectRecombinación genéticaes_ES
dc.subjectHistonases_ES
dc.subjectMutaciónes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histoneses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repaires_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damagees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replicationes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutationes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probabilityes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetices_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Chromosome Structures::Chromatines_ES
dc.titleHistone H3E73Q and H4E53A mutations cause recombinogenic DNA damagees_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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