RT Journal Article
T1 Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
A1 Ortega, Pedro
A1 García-Pichardo, Desiré
A1 San Martin-Alonso, Marta
A1 Rondón, Ana G.
A1 Gómez-González, Belén
A1 Aguilera, Andrés
K1 Chromatin
K1 DNA replication
K1 Recombination
K1 Histone mutants
K1 Cromatina
K1 Replicación del ADN
K1 Recombinación genética
K1 Histonas
K1 Mutación
AB The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage can result in genetic alterations and subsequent development of cancer and other genetic diseases. Here, we identified two mutations in conserved residues of histone H3 and histone H4 (H3E73Q and H4E53A) that increase recombinogenic DNA damage. Our results suggest that the accumulation of DNA damage in these histone mutants is largely independent on transcription and might arise as a consequence of problems occurring during DNA replication. This study uncovers the relevance of H3E73 and H4E53 residues in the protection of genome integrity.
PB Shared Science Publishers
YR 2020
FD 2020-04-24
LK http://hdl.handle.net/10668/3568
UL http://hdl.handle.net/10668/3568
LA en
NO Ortega P, García-Pichardo D, San Martin-Alonso M, Rondón AG, Gómez-González B, Aguilera A. Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microb Cell. 2020 Apr 24;7(7):190-198.
DS RISalud
RD Apr 19, 2025