Publication:
Reply to "CMV merits further evolutionary and biological view".

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Date

2020-04-12

Authors

Gutierrez-Gutierrez, Belen
Perez-Nadales, Elena
Rodriguez-Baño, Jesus
Torre-Cisneros, Julian

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Elsevier
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Abstract

We thank Ferhat Arslan for this letter. Biological significance is certainly the most important aspect in biomedical research; however, statistics provide a powerful tool to reveal associations between biological variables. In our study, we aimed to identify predictor variables for mortality in solid organ transplant recipients with carbapenemase-producing Enterobacteriaceae-bloodstream infections (CPE-BSI) regardless of their causal associations and to analyze the predictive capacity of the model. However, in this case, we consider there is a plausible clinical justification for the variables and interaction obtained in our model. Thus, for the interaction term, it could be interpreted that in high-risk patients, the mortality associated with CPE infection is so high that the impact of a previous cytomegalovirus (CMV) infection would not involve higher mortality.

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MeSH Terms

Bacterial proteins
Cytomegalovirus
Cytomegalovirus infections
Humans
Lymphopenia
Transplant recipients
beta-Lactamases

DeCS Terms

Citomegalovirus
Infecciones por citomegalovirus
Linfopenia
Proteínas bacterianas
Receptores de trasplantes

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Keywords

Antibiotic drug resistance, Clinical research/practice, Infection and infectious agents-bacterial, Infectious disease

Citation

Gutiérrez-Gutiérrez B, Pérez-Nadales E, Rodríguez-Baño J, Torre-Cisneros J. Reply to "CMV merits further evolutionary and biological view". Am J Transplant. 2020 May;20(5):1467-1468