Publication:
Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue.

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Date

2022-04-07

Authors

Martinez-Torija, Mario
Esteban, Pedro F
Espino-Rodriguez, Francisco Javier
Paniagua-Torija, Beatriz
Molina-Holgado, Eduardo
Ceruelo, Silvia
Barroso-Garcia, Gemma
Arandilla, Alba G
Lopez-Almodovar, Luis F
Arevalo-Martin, Angel

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MDPI
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Abstract

The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known. Spinal cord injury (SCI) patients who underwent reconstructive surgery for pressure ulcers (PUs) before and during the COVID-19 pandemic were included in this study. The patient's postoperative progression was registered, and the subcutaneous white adipose tissue (s-WAT) surrounding the ulcers was analyzed by proteomic and immunohistochemical assays to identify the molecular/cellular signatures of impaired recovery. Patients with SCI and a COVID-19-positive diagnosis showed worse recovery and severe postoperative complications, requiring reintervention. Several proteins were upregulated in the adipose tissue of these patients. Among them, CKMT2 and CKM stood out, and CKM increased for up to 60 days after the COVID-19 diagnosis. Moreover, CKMT2 and CKM were largely found in MGCs within the s-WAT of COVID patients. Some of these proteins presented post-translational modifications and were targeted by autoantibodies in the serum of COVID patients. Overall, our results indicate that CKMT2, CKM, and the presence of MGCs in the adipose tissue surrounding PUs in post-COVID patients could be predictive biomarkers of postsurgical complications. These results suggest that the inflammatory response in adipose tissue may underlie the defective repair seen after surgery.

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MeSH Terms

Adipose tissue
COVID-19
COVID-19 testing
Creatine kinase
Creatine kinase, mitochondrial form
Humans
Pandemics
Pressure ulcer
Proteomics
SARS-CoV-2
Spinal cord injuries
Suppuration
Up-regulation

DeCS Terms

Creatina quinasa
Forma mitocondrial de la creatina-quinasa
Pandemias
Proteómica
Prueba de COVID-19
Supuración
Tejido adiposo
Traumatismos de la médula espinal
Úlcera por presión

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Keywords

CKs, COVID-19, MGCs, PU, SARS-CoV-2, SCI, Adipose tissue, Autoantibodies, Proteomics, Surgery

Citation

Martínez-Torija M, Esteban PF, Espino-Rodríguez FJ, Paniagua-Torija B, Molina-Holgado E, Ceruelo S, et al. Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue. Cells. 2022 Apr 9;11(8):1282