RT Journal Article
T1 Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue.
A1 Martinez-Torija, Mario
A1 Esteban, Pedro F
A1 Espino-Rodriguez, Francisco Javier
A1 Paniagua-Torija, Beatriz
A1 Molina-Holgado, Eduardo
A1 Ceruelo, Silvia
A1 Barroso-Garcia, Gemma
A1 Arandilla, Alba G
A1 Lopez-Almodovar, Luis F
A1 Arevalo-Martin, Angel
A1 Moreno, Juan Antonio
A1 Garcia-Ovejero, Daniel
A1 Duran-Ruiz, Mª Carmen
A1 Moreno-Luna, Rafael
K1 CKs
K1 COVID-19
K1 MGCs
K1 PU
K1 SARS-CoV-2
K1 SCI
K1 Adipose tissue
K1 Autoantibodies
K1 Proteomics
K1 Surgery
AB The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known. Spinal cord injury (SCI) patients who underwent reconstructive surgery for pressure ulcers (PUs) before and during the COVID-19 pandemic were included in this study. The patient's postoperative progression was registered, and the subcutaneous white adipose tissue (s-WAT) surrounding the ulcers was analyzed by proteomic and immunohistochemical assays to identify the molecular/cellular signatures of impaired recovery. Patients with SCI and a COVID-19-positive diagnosis showed worse recovery and severe postoperative complications, requiring reintervention. Several proteins were upregulated in the adipose tissue of these patients. Among them, CKMT2 and CKM stood out, and CKM increased for up to 60 days after the COVID-19 diagnosis. Moreover, CKMT2 and CKM were largely found in MGCs within the s-WAT of COVID patients. Some of these proteins presented post-translational modifications and were targeted by autoantibodies in the serum of COVID patients. Overall, our results indicate that CKMT2, CKM, and the presence of MGCs in the adipose tissue surrounding PUs in post-COVID patients could be predictive biomarkers of postsurgical complications. These results suggest that the inflammatory response in adipose tissue may underlie the defective repair seen after surgery.
PB MDPI
YR 2022
FD 2022-04-07
LK http://hdl.handle.net/10668/20929
UL http://hdl.handle.net/10668/20929
LA en
NO Martínez-Torija M, Esteban PF, Espino-Rodríguez FJ, Paniagua-Torija B, Molina-Holgado E, Ceruelo S, et al. Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue. Cells. 2022 Apr 9;11(8):1282
DS RISalud
RD Apr 12, 2025