Publication: Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors.
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Date
2019-05-17
Authors
Colombé, Cindy
Le Guével, Xavier
Martin-Serrano, Angela
Henry, Maxime
Porret, Estelle
Comby-Zerbino, Clothilde
Antoine, Rodolphe
Atallah, Ihab
Busser, Benoit
Coll, Jean-Luc
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Abstract
With the objective to evaluate the potential of ultra-small gold (Au) nanoclusters (NCs) for optical image-guided surgery, we synthesized and characterized AuNCs shelled by zwitterionic or pegylated ligands. The toxicity of the different AuNCs was evaluated on the Head and Neck Squamous Cell Carcinoma (HNSCC) CAL-33 and SQ20B cell lines in vitro. The safer AuNCs were administrated intravenously to mice for the determination of the pharmacokinetic properties. Biodistributions were performed on orthotopic CAL-33 HNSCC-bearing mice. Finally, the AuNCs were used for image-guided surgery, allowing the increase of the survival time vs. control animals, and the number of animals without any local recurrence.
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MeSH Terms
Animals
Cell Line, Tumor
Cell Survival
Contrast Media
Endocytosis
Gold
Head and Neck Neoplasms
Humans
Metal Nanoparticles
Mice
Surgery, Computer-Assisted
Tissue Distribution
Cell Line, Tumor
Cell Survival
Contrast Media
Endocytosis
Gold
Head and Neck Neoplasms
Humans
Metal Nanoparticles
Mice
Surgery, Computer-Assisted
Tissue Distribution
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CIE Terms
Keywords
Carcinoma, Gold nanoclusters, Head and Neck, Image-guided surgery, Nanomedicine