RT Journal Article
T1 Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors.
A1 Colombe, Cindy
A1 Le-Guevel, Xavier
A1 Martin-Serrano, Angela
A1 Henry, Maxime
A1 Porret, Estelle
A1 Comby-Zerbino, Clothilde
A1 Antoine, Rodolphe
A1 Atallah, Ihab
A1 Busser, Benoit
A1 Coll, Jean-Luc
A1 Righini, Christian Adrien
A1 Sancey, Lucie
K1 Carcinoma
K1 Gold nanoclusters
K1 Head and Neck
K1 Image-guided surgery
K1 Nanomedicine
AB With the objective to evaluate the potential of ultra-small gold (Au) nanoclusters (NCs) for optical image-guided surgery, we synthesized and characterized AuNCs shelled by zwitterionic or pegylated ligands. The toxicity of the different AuNCs was evaluated on the Head and Neck Squamous Cell Carcinoma (HNSCC) CAL-33 and SQ20B cell lines in vitro. The safer AuNCs were administrated intravenously to mice for the determination of the pharmacokinetic properties. Biodistributions were performed on orthotopic CAL-33 HNSCC-bearing mice. Finally, the AuNCs were used for image-guided surgery, allowing the increase of the survival time vs. control animals, and the number of animals without any local recurrence.
PB Elsevier
YR 2019
FD 2019-06-14
LK http://hdl.handle.net/10668/13984
UL http://hdl.handle.net/10668/13984
LA en
NO Colombé C, Le Guével X, Martin-Serrano A, Henry M, Porret E, Comby-Zerbino C, et al. Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors. Nanomedicine. 2019 Aug;20:102011
DS RISalud
RD Apr 11, 2025