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Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors.

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dc.contributor.authorColombe, Cindy
dc.contributor.authorLe-Guevel, Xavier
dc.contributor.authorMartin-Serrano, Angela
dc.contributor.authorHenry, Maxime
dc.contributor.authorPorret, Estelle
dc.contributor.authorComby-Zerbino, Clothilde
dc.contributor.authorAntoine, Rodolphe
dc.contributor.authorAtallah, Ihab
dc.contributor.authorBusser, Benoit
dc.contributor.authorColl, Jean-Luc
dc.contributor.authorRighini, Christian Adrien
dc.contributor.authorSancey, Lucie
dc.date.accessioned2023-01-25T13:33:39Z
dc.date.available2023-01-25T13:33:39Z
dc.date.issued2019-06-14
dc.description.abstractWith the objective to evaluate the potential of ultra-small gold (Au) nanoclusters (NCs) for optical image-guided surgery, we synthesized and characterized AuNCs shelled by zwitterionic or pegylated ligands. The toxicity of the different AuNCs was evaluated on the Head and Neck Squamous Cell Carcinoma (HNSCC) CAL-33 and SQ20B cell lines in vitro. The safer AuNCs were administrated intravenously to mice for the determination of the pharmacokinetic properties. Biodistributions were performed on orthotopic CAL-33 HNSCC-bearing mice. Finally, the AuNCs were used for image-guided surgery, allowing the increase of the survival time vs. control animals, and the number of animals without any local recurrence.
dc.description.versionSi
dc.identifier.citationColombé C, Le Guével X, Martin-Serrano A, Henry M, Porret E, Comby-Zerbino C, et al. Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors. Nanomedicine. 2019 Aug;20:102011
dc.identifier.doi10.1016/j.nano.2019.04.014
dc.identifier.essn1549-9642
dc.identifier.pmid31103735
dc.identifier.unpaywallURLhttps://www.sciencedirect.com/science/article/am/pii/S1549963419300954
dc.identifier.urihttp://hdl.handle.net/10668/13984
dc.journal.titleNanomedicine : nanotechnology, biology, and medicine
dc.journal.titleabbreviationNanomedicine
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationCentro Andaluz de Nanomedicina y Biotecnología-BIONAND
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number1
dc.provenanceRealizada la curación de contenido 04/04/2025
dc.publisherElsevier
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.publisherversionhttps://linkinghub.elsevier.com/retrieve/pii/S1549-9634(19)30095-4
dc.rights.accessRightsRestricted Access
dc.subjectCarcinoma
dc.subjectGold nanoclusters
dc.subjectHead and Neck
dc.subjectImage-guided surgery
dc.subjectNanomedicine
dc.subject.decsCarcinoma de Células Escamosas de Cabeza y Cuello
dc.subject.decsCirugía Asistida por Computador
dc.subject.decsLínea Celular
dc.subject.decsLigandos
dc.subject.decsTécnicas In Vitro
dc.subject.meshAnimals
dc.subject.meshCell Line, Tumor
dc.subject.meshCell Survival
dc.subject.meshContrast Media
dc.subject.meshEndocytosis
dc.subject.meshGold
dc.subject.meshHead and Neck Neoplasms
dc.subject.meshHumans
dc.subject.meshMetal Nanoparticles
dc.subject.meshMice
dc.subject.meshSurgery, Computer-Assisted
dc.subject.meshTissue Distribution
dc.titleGold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number20
dspace.entity.typePublication

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