Publication:
Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles.

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Date

2018-10-24

Authors

Fernandez-Ponce, Cecilia
Muñoz-Miranda, Juan P
de Los Santos, Desire M
Aguado, Enrique
Garcia-Cozar, Francisco
Litran, Rocio

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Abstract

Hydrophilic and homogeneous sub-10 nm blue light-emitting gold nanoparticles (NPs) functionalized with different capping agents have been prepared by simple chemical routes. Structure, average, size, and surface characteristics of these NPs have been widely studied, and the stability of colloidal NP solutions at different pH values has been evaluated. Au NPs show blue PL emission, particularly in the GSH capped NPs, in which the thiol-metal core transference transitions considerably enhance the fluorescent emission. The influence of capping agent and NP size on cytotoxicity and on the fluorescent emission are analyzed and discussed in order to obtain Au NPs with suitable features for biomedical applications. Cytotoxicity of different types of gold NPs has been determined using NPs at high concentrations in both tumor cell lines and primary cells. All NPs used show high biocompatibility with low cytotoxicity even at high concentration, while Au-GSH NPs decrease viability and proliferation of both a tumor cell line and primary lymphocytes.

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MeSH Terms

Blue light
Gold
Metal nanoparticles
Cell line, tumor
Lymphocytes
Cell proliferation
Hydrogen-ion concentration

DeCS Terms

Concentración de iones de hidrógeno
Linfocitos
Luz azul
Línea celular tumoral
Nanopartículas del metal
Oro
Proliferación celular

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Keywords

Agent, Capping, Cell viability, Cytotoxicity, GSH, Gold nanoparticles, Photoluminescence, Proliferation, Semiconfocal microscopy

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